List of Fluoroquinolones

Courtesy of Wikipedia

The first generation is rarely used today. Nalidixic acid was added to the OEHHA Prop 65 list as a carcinogen on 15 May 1998.[75] A number of the second-, third-, and fourth-generation drugs have been removed from clinical practice due to severe toxicity issues or discontinued by their manufacturers.

The drugs most frequently prescribed today consist of Avelox (moxifloxacin), Cipro (ciprofloxacin), Levaquin (levofloxacin), and, to some extent, their generic equivalents.

First-generation[edit]

Second-generation[edit]

The second-generation class is sometimes subdivided into “Class 1” and “Class 2”.[77]

Third-generation[edit]

Unlike the first- and second-generations, the third-generation is active against streptococci.[77]

Fourth-generation[edit]

Fourth-generation fluoroquinolones act at DNA gyrase and topoisomerase IV.[81] This dual action slows development of resistance.

In development[edit]

Veterinary use[edit]

The quinolones have been widely used in agriculture, and several agents have veterinary, but not human, applications.